Friedel-Crafts alkylation of indoles with epoxides using PW12-APTES@SBA-15

Ammonium monovanadate: a versatile and reusable catalyst for Friedel-Crafts alkylation and Michael addition of indoles

Ammonium monovanadate (NH4VO3) has been devoted as an efficient, commercially available, eco-friendly and reusable catalyst for the synthesis of bis(indolyl)methanes (BIMs), oxindole derivatives and also Michael adducts of indoles at 50 °C under solvent-free conditions. The reusability of this solid acid catalyst in addition with its selectivity has also been examined.

Ammonium monovanadate: a versatile and reusable catalyst for Friedel-Crafts alkylation and Michael addition of indoles

Ammonium monovanadate (NH4VO3) has been devoted as an efficient, commercially available, eco-friendly and reusable catalyst for the synthesis of bis(indolyl)methanes (BIMs), oxindole derivatives and also Michael adducts of indoles at 50 °C under solvent-free conditions. The reusability of this solid acid catalyst in addition with its selectivity has also been examined.

Friedel-Crafts alkylation of Phenol using Ionic Liquid as Catalyst

Enhanced Efficiency of Thiourea Catalysts by External Brønsted Acids in the Friedel–Crafts Alkylation of Indoles

A novel study of external Brønsted acid-assisted thiourea catalysts in the asymmetric FriedelCrafts alkylation of indoles with nitroalkenes is reported. The final 3-substituted indoles derivatives are synthesized with better results by cooperative effect between chiral thiourea and a Brønsted acid additive (1a·HA), than those obtained with sole thiourea catalyst 1a. The effect of diverse catal...

Biocatalytic Friedel-Crafts alkylation using non-natural cofactors.

The formation of C C bonds is a central aspect of synthetic organic chemistry. However, in biocatalysis only few enzymes capable to perform this reaction are known, among which aldolases, transketolases, and hydroxynitril lyases have been investigated thoroughly. Some have even found their way into industrial applications. Friedel–Crafts alkylation is a classic organic reaction of great importa...

Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.